Effect of acute acid-base disturbances on ErbB1/2 tyrosine phosphorylation in rabbit renal proximal tubules
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چکیده
منابع مشابه
Potassium transport across renal distal tubules during acid-base disturbances.
~MALNIC, GERHARD, MARGARIDA DE MELLO AIRES, AND GERHARD GIEBISCH. Potassium transport across renal distal tubules during acid-base disturbances. Am. J. Physiol. 221(4) : 1192-1208. 197 1 .-Free-flow samples of tubular fluid (TF) were collected from superficial nephrons of rat kidneys for the analysis of potassium (K), pH, bicarbonate and inulin-W. Rats were subjected to metabolic or respiratory...
متن کاملEffect of acid-base status in vivo on bicarbonate transport by rabbit renal tubules in vitro.
In previous studies, when rabbit cortical collecting ducts were studied under standard conditions in vitro, bicarbonate transport was conditioned by the acid-base status in vivo of the animals from which the tubules were obtained. The collecting ducts absorbed bicarbonate if the animals were acidotic (from ammonium chloride administration), but they secreted bicarbonate if the animals were alka...
متن کاملEffect of acute acid-base disturbances on the phosphorylation of phospholipase C-c1 and Erk1/2 in the renal proximal tubule
The renal proximal tubule (PT) plays a major role in whole-body pH homeostasis by secreting H into the tubule lumen. Previous work demonstrated that PTs respond to basolateral changes in [CO2] and [HCO 3 ] by appropriately altering H secretion—responses blocked by the ErbB inhibitor PD168393, or by eliminating signaling through AT1 angiotensin receptors. In the present study, we analyze phospho...
متن کاملEffect of acute acid-base disturbances on the phosphorylation of phospholipase C-γ1 and Erk1/2 in the renal proximal tubule
The renal proximal tubule (PT) plays a major role in whole-body pH homeostasis by secreting H(+) into the tubule lumen. Previous work demonstrated that PTs respond to basolateral changes in [CO2] and [HCO3-] by appropriately altering H(+) secretion-responses blocked by the ErbB inhibitor PD168393, or by eliminating signaling through AT1 angiotensin receptors. In the present study, we analyze ph...
متن کاملEffect of α-ketoglutarate on organic anion transport in single rabbit renal proximal tubules.
The effect of exogenous α-ketoglutarate (αKG) and the peritubular Na+-dicarboxylate (Na-DC) cotransporter on organic anion/dicarboxylate (OA/DC) exchange in S2 segments of single, nonperfused rabbit proximal tubules was measured using 1 μM fluorescein (FL), a model OA, and epifluorescence microscopy. The effect of different transmembrane distributions of 10 μM αKG on peritubular FL uptake was m...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2013
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00307.2013